Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Akr1c12tm1e(KOMP)Wtsi
Name:	aldo-keto reductase family 1, member C12; targeted mutation 1e, Wellcome Trust Sanger Institute
MGI ID:	MGI:5426567
Gene:	Akr1c12  Location: Chr13:4318171-4329398 bp, - strand  Genetic Position: Chr13, 2.39 cM
IMPC:	Akr1c12 gene page

Mutant Cell Lines:	EPD0770_2_B12, EPD0770_2_D11, EPD0876_5_G10
Germline Transmission:	Unknown
Parent Cell Line:	JM8A3.N1 (ES Cell)
Strain of Origin:	C57BL/6N-Atm1Brd
Project Collection:	KOMP-CSD

Allele Type:    Targeted (Null/knockout, Reporter) Mutation:    Insertion     Vector: L1L2_Bact_P   Mutation details: The L1L2_Bact_P cassette was inserted at position 4325241 of Chromosome 13 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. Insertion of this cassette creates a reporter knockout mouse. Cre expression will remove the neomycin selection cassette. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:148605, J:173534)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 1 line available
Carrying any Akr1c12 Mutation:	23 strains or lines available

Original:	J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009;
All:	2 reference(s)