Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Zbtb46tm1Kmm
Name:	zinc finger and BTB domain containing 46; targeted mutation 1, Kenneth Murphy
MGI ID:	MGI:5320483
Synonyms:	Zbtb46gfp
Gene:	Zbtb46  Location: Chr2:181029555-181101219 bp, - strand  Genetic Position: Chr2, 103.63 cM, cytoband H4
Alliance:	Zbtb46tm1Kmm page

Germline Transmission:	Earliest citation of germline transmission: J:184205
Parent Cell Line:	EDJ22 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting vector was designed to replace exon 2, which encodes the start codon and the BTB domain of the zinc finger and BTB domain, with an enhanced green fluorescent protein followed by a polyadenylation signal and a floxed neo cassette. Microarray analysis confirmed the absence of transcript expression in dendritic cells. (J:184205)

Generation of the Zbtb46tm1Kmm allele

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Zbtb46 Mutation:	36 strains or lines available

Original:	J:184205 Satpathy AT, et al., Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages. J Exp Med. 2012 Jun 4;209(6):1135-52
All:	16 reference(s)