Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Lrrc7tm1.2Mabk
Name:	leucine rich repeat containing 7; targeted mutation 1.2, Mary B Kennedy
MGI ID:	MGI:5320434
Synonyms:	Densinflox, Lrrc7flox
Gene:	Lrrc7  Location: Chr3:157788528-158267858 bp, - strand  Genetic Position: Chr3, 81.68 cM
Alliance:	Lrrc7tm1.2Mabk page

Germline Transmission:	Earliest citation of germline transmission: J:177836
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A targeting vector was designed to insert a single loxP site upstream of exon 3, and a loxP-flanked hygromycin resistance (hygro) cassette downstream of exon 3. Cre-mediated recombination removed the hygro cassette and left exon 3 floxed. (J:177836)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lrrc7 Mutation:	94 strains or lines available

Original:	J:177836 Carlisle HJ, et al., Deletion of Densin-180 Results in Abnormal Behaviors Associated with Mental Illness and Reduces mGluR5 and DISC1 in the Postsynaptic Density Fraction. J Neurosci. 2011 Nov 9;31(45):16194-207
All:	1 reference(s)