Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(Th-FTH1)1Jkan
Name:	transgene insertion 1, Julie Andersen
MGI ID:	MGI:5314634
Transgene:	Tg(Th-FTH1)1Jkan  Location: unknown
Alliance:	Tg(Th-FTH1)1Jkan page

Strain of Origin:

(C57BL/6 x DBA/2)F1

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Tg(Th-FTH1)1Jkan expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human FTH1 (2495) Fth1  (MGI:95588)   Tg(Th-FTH1)1Jkan expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Homolog in Mouse Note rat Th (25085) Th  (MGI:98735)   Mutation details: The transgene construct contained a 2.6kb fragment of the human FTH1 (ferritin, heavy polypeptide 1) gene lacking the iron-response element (IRE) under the control of the rat Th (tyrosine hydroxylase) promoter, and SV40 polyA signal Line 1 was generated. (J:139481)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:139481 Kaur D, et al., Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's disease. Neuron. 2003 Mar 27;37(6):899-909
All:	1 reference(s)