Aplp1tm1e(EUCOMM)Hmgu
Targeted Allele Detail
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Symbol: |
Aplp1tm1e(EUCOMM)Hmgu |
Name: |
amyloid beta precursor like protein 1; targeted mutation 1e, Helmholtz Zentrum Muenchen GmbH |
MGI ID: |
MGI:5314402 |
Gene: |
Aplp1 Location: Chr7:30134407-30144960 bp, - strand Genetic Position: Chr7, 18.32 cM
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Alliance: |
Aplp1tm1e(EUCOMM)Hmgu page
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IMPC: |
Aplp1 gene page |
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Mutant Cell Lines: |
HEPD0709_6_A10, HEPD0709_6_A11, HEPD0709_6_A12, HEPD0709_6_B09, HEPD0709_6_B10, HEPD0709_6_B11, HEPD0709_6_B12, HEPD0709_6_C09, HEPD0709_6_C10, HEPD0709_6_D09, HEPD0709_6_D11, HEPD0709_6_E09, HEPD0709_6_E10, HEPD0709_6_E11, HEPD0709_6_E12, HEPD0709_6_F09, HEPD0709_6_F11, HEPD0709_6_G09, HEPD0709_6_G11, HEPD0709_6_G12, HEPD0709_6_H09, HEPD0709_6_H10, HEPD0709_6_H11, HEPD0709_6_H12 |
Germline Transmission: |
Earliest citation of germline transmission:
J:204812
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Parent Cell Line: |
JM8A3.N1 (ES Cell)
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Strain of Origin: |
C57BL/6N-Atm1Brd
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Project Collection: |
EUCOMM
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutation: |
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Insertion
Vector: L1L2_Bact_P
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Mutation details: The L1L2_Bact_P cassette was inserted at position 30143128 of Chromosome 7 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. Insertion of this cassette creates a reporter knockout mouse. Cre expression will remove the neomycin selection cassette. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml
(J:157065)
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Original: |
J:157065 Helmholtz Zentrum Muenchen GmbH, Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu). MGI Direct Data Submission. 2010-2015; |
All: |
2 reference(s) |
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