b2b251Clo Chemically induced Allele Detail MGI Mouse (MGI:5313696)

b2b251Clo
Chemically induced Allele Detail

Summary

Symbol:	b2b251Clo
Name:	Mutant line 251; Bench to Bassinet Program (B2B/CVDC), mutation 251 Cecilia Lo
MGI ID:	MGI:5313696
Gene:	b2b251Clo Location: unknown
Alliance:	b2b251Clo page

Malalignment of the great arteries suggest double outlet right ventricle (DORV) in mutant 251-007-1 (E15.5), which was subsequently confirmed by EFIC imaging.

Show the 15 phenotype image(s) involving this allele.

Mutation
origin

Strain of Origin:	C57BL/6J
Project Collection:	B2B/CvDC

Mutation
description

Allele Type:		Chemically induced (ENU)
Mutation:		Undefined
		This ENU-induced mutation was isolated in a screen at the University of Pittsburgh.

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any b2b251Clo Mutation:	1 strain or line available

Notes

Summative Diagnosis:
Cardiovascular defect: Double outlet right ventricle (DORV), overriding aorta, perimembranous and muscular ventricular septal defects (VSD), and one mutant with hypoplastic transverse arch.
Non-cardiovascular phenotype: Cystic lungs.

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID	Code Description
1220	Tubular hypoplasia of aorta + coarctation
1310	Ventricular septal defect, membranous
1320	Ventricular septal defect, muscular
1340	Ventricular septal defect, ECD type
3810	Heart disease
4200	Respiratory anomaly

References

Original:	J:175213 Lo C, Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC). MGI Direct Data Submission (B2B/CvDC). 2011-09-12;
All:	2 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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