Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gt(ROSA)26Sortm1(RAC1*)Jkis
Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Joseph L Kissil
MGI ID:	MGI:5307896
Synonyms:	Rosa26-LSL-Rac1b
Gene:	Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance:	Gt(ROSA)26Sortm1(RAC1*)Jkis page

Germline Transmission:	Earliest citation of germline transmission: J:187582
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Gt(ROSA)26Sortm1(RAC1*)Jkis expresses 1 gene Knock-in expresses: Organism Expressed Gene Homolog in Mouse Note human RAC1 (5879) Rac1  (MGI:97845)   Mutation details: Human RAS-related C3 botulinum substrate 1 (Rac1) isoform b cDNA was inserted into a Gt(ROSA)26Sor vector, downstream of the loxP-flanked cassette, which contains a neomycin selectable marker and a transcriptional stop sequence. (J:187582)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:	942 strains or lines available

Original:	J:187582 Zhou C, et al., The Rac1 splice form Rac1b promotes K-ras-induced lung tumorigenesis. Oncogene. 2013 Feb 14;32(7):903-9
All:	2 reference(s)