Tg(Thy1-MAPT*)3608Gds
Transgene Detail
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Symbol: |
Tg(Thy1-MAPT*)3608Gds |
Name: |
transgene insertion 3608, Gerard Schellenberg |
MGI ID: |
MGI:5305850 |
Synonyms: |
E391-3608, THY1.2::TauE391 |
Transgene: |
Tg(Thy1-MAPT*)3608Gds Location: unknown
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Alliance: |
Tg(Thy1-MAPT*)3608Gds page
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Strain of Origin: |
C57BL/6 x C3H
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Transgene Type: |
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Transgenic (Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(Thy1-MAPT*)3608Gds expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
MAPT (4137) |
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Mutation details: The transgenic construct contains the 4R1N tau isoform truncated at amino acid position E391(glutamic acid) and under the direction of the Thy1b (Thy1.2) neuron specific promoter. The construct contains sequences encoded by alternatively spliced exons 2 and 10 and has 4 microtubule repeats. Lines 3608 and 3610 were generated.
(J:179578)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:179578 McMillan PJ, et al., Truncation of tau at E391 promotes early pathologic changes in transgenic mice. J Neuropathol Exp Neurol. 2011 Nov;70(11):1006-19 |
All: |
1 reference(s) |
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