Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Dp(16Tiam1-Kcnj6)6Yey
Name:	duplication, Chr 16, Y Eugene Yu 6
MGI ID:	MGI:5305765
Synonyms:	Dp(16)2Yey
Gene:	Dp(16Tiam1-Kcnj6)6Yey  Location: Chr16:89583999-94798555 bp  Genetic Position: Chr16, Syntenic

Germline Transmission:	Earliest citation of germline transmission: J:180201
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Not Applicable) Mutation:    Insertion   Dp(16Tiam1-Kcnj6)6Yey involves 110 genes/genome features (Gm22933, Gm22344, Gm22745 ...) View all   Mutation details: ES cells were targeted twice with MICER vectors inserting 403 kb upstream of the Tiam1 gene and 155 kb downstream of Kcnj6. Transient transfection using a cre-expression vector resulted in recombination between the two targeted sites creating a duplication/deficiency allele pair. (J:180201)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Dp(16Tiam1-Kcnj6)6Yey Mutation:	2 strains or lines available

Original:	J:180201 Liu C, et al., Genetic analysis of Down syndrome-associated heart defects in mice. Hum Genet. 2011 Nov;130(5):623-32
All:	2 reference(s)