Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Il20ratm1.1Misc Name: interleukin 20 receptor, alpha; targeted mutation 1.1, Ming-Shi Chang MGI ID: MGI:5302406 Gene: Il20ra  Location: Chr10:19588318-19635801 bp, + strand  Genetic Position: Chr10, 8.76 cM Alliance: Il20ratm1.1Misc page

Il20ratm1.1Misc/Il20ratm1.1Misc mice are protected from ovariectomy-induced bone loss Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:177783
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 2. Cre-mediated recombination removed exon 2 and the neo cassette. Western blot analysis confirmed the absence of protein expression in the lungs. (J:177783)

Generation of the Il20ratm1.1Misc allele

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Il20ra Mutation:	30 strains or lines available

Original:	J:177783 Hsu YH, et al., Anti-IL-20 monoclonal antibody inhibits the differentiation of osteoclasts and protects against osteoporotic bone loss. J Exp Med. 2011 Aug 29;208(9):1849-61
All:	4 reference(s)