Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(Prnp-TARDBP*M337V)4Ptrc
Name:	transgene insertion 4, Leonard Petrucelli
MGI ID:	MGI:5301818
Synonyms:	hTDP-43M337V line 4, hTDP-43subM337V/sub
Transgene:	Tg(Prnp-TARDBP*M337V)4Ptrc  Location: unknown
Alliance:	Tg(Prnp-TARDBP*M337V)4Ptrc page

Strain of Origin:

C57BL/6

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Tg(Prnp-TARDBP*M337V)4Ptrc expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human TARDBP (23435) Tardbp  (MGI:2387629)   Mutation details: The hTDP-43 transgene was designed with the mouse prion protein (Prnp) promoter driving expression of a mutant form of the human TARDBP gene modified to have the methionine to valine substitution at codon 337 (M337V). Line 4 was generated. (J:179348)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:179348 Xu YF, et al., Expression of mutant TDP-43 induces neuronal dysfunction in transgenic mice. Mol Neurodegener. 2011;6:73
All:	6 reference(s)