Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Kitltm1.1Sjm
Name:	kit ligand; targeted mutation 1.1, Sean J Morrison
MGI ID:	MGI:5300819
Synonyms:	Scfgfp
Gene:	Kitl  Location: Chr10:99851492-99936278 bp, + strand  Genetic Position: Chr10, 51.4 cM
Alliance:	Kitltm1.1Sjm page

Germline Transmission:	Earliest citation of germline transmission: J:180431
Parent Cell Line:	W4 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting vector was designed to replace exon 2 with EGFP (in frame) and an FRT-flanked neomycin resistance cassette. The neomycin resistance cassette was removed by flp-mediated recombination. qRT-PCR confirmed the absence of transcript expression in the liver. (J:180431)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kitl Mutation:	92 strains or lines available

Original:	J:180431 Ding L, et al., Endothelial and perivascular cells maintain haematopoietic stem cells. Nature. 2012 Jan 26;481(7382):457-62
All:	14 reference(s)