Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Kittm1.1Sraf
Name:	KIT proto-oncogene receptor tyrosine kinase; targeted mutation 1.1, Shahin Rafii
MGI ID:	MGI:5297728
Synonyms:	c-Kit lox66-71
Gene:	Kit  Location: Chr5:75735647-75817382 bp, + strand  Genetic Position: Chr5, 39.55 cM
Alliance:	Kittm1.1Sraf page

Germline Transmission:	Earliest citation of germline transmission: J:178071
Parent Cell Line:	C2J (ES Cell)
Strain of Origin:	B6(Cg)-Tyrc-2J/J

Allele Type:    Targeted (Null/knockout, Reporter) Mutation:    Insertion   Mutation details: A construct containing a lox66 site, inverted GFP gene, lox71, and FRT-flanked neo cassette was inserted between exon 8 and exon 9. Flp-mediated recombination removed the neo cassette. (J:178071)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kit Mutation:	179 strains or lines available

Original:	J:178071 Kimura Y, et al., c-Kit-Mediated Functional Positioning of Stem Cells to Their Niches Is Essential for Maintenance and Regeneration of Adult Hematopoiesis. PLoS One. 2011;6(10):e26918
All:	2 reference(s)