Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Apba3tm1.2Ski
Name:	amyloid beta precursor protein binding family A member 3; targeted mutation 1.2, Motoharu Seiki
MGI ID:	MGI:5293147
Gene:	Apba3  Location: Chr10:81102799-81109081 bp, + strand  Genetic Position: Chr10, 39.72 cM
Alliance:	Apba3tm1.2Ski page

Germline Transmission:	Earliest citation of germline transmission: J:176742
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Cre-mediated recombination removed exons 2 and 3 and the neo cassette. The absence of protein expression was confirmed by western blot analysis on brain, liver, kidney, and muscle extract. (J:176742)

Generation of the Apba3tm1.2Ski allele

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Apba3 Mutation:	22 strains or lines available

Original:	J:176742 Hara T, et al., Deletion of the Mint3/Apba3 gene in mice abrogates macrophage functions and increases resistance to lipopolysaccharide-induced septic shock. J Biol Chem. 2011 Sep 16;286(37):32542-51
All:	5 reference(s)