Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Akap12tm1Ihg
Name:	A kinase anchor protein 12; targeted mutation 1, Irwin H Gelman
MGI ID:	MGI:5286076
Synonyms:	mSSeCKS-
Gene:	Akap12  Location: Chr10:4216380-4309470 bp, + strand  Genetic Position: Chr10, 2.06 cM
Alliance:	Akap12tm1Ihg page

Germline Transmission:	Earliest citation of germline transmission: J:138882
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A lacZ followed by a neomycin selection cassette were inserted in exon2. Western blot analysis demonstrated the absence of all three major isoforms (alpha, beta, gamma). (J:138882)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

9 anatomical structure(s)

List all tumor models in MMHCdb carrying Akap12tm1Ihg

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Akap12 Mutation:	215 strains or lines available

Original:	J:138882 Akakura S, et al., Loss of the SSeCKS/Gravin/AKAP12 gene results in prostatic hyperplasia. Cancer Res. 2008 Jul 1;68(13):5096-103
All:	10 reference(s)