Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sema5btm1.2Alk
Name:	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B; targeted mutation 1.2, Alex L Kolodkin
MGI ID:	MGI:5284883
Synonyms:	Sema5B-
Gene:	Sema5b  Location: Chr16:35361517-35485103 bp, + strand  Genetic Position: Chr16, 25.37 cM
Alliance:	Sema5btm1.2Alk page

Germline Transmission:	Earliest citation of germline transmission: J:174679
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting vector was designed to insert a loxP site upstream of exon 2, and a frt-flanked neomycin resistance (neo) cassette followed by a second loxP site just downstream of exon 2 of the semaphorin 5B (Sema5b) targeted gene. Cre-mediated recombination removed exon 2 and the neo cassette. (J:174679)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sema5b Mutation:	80 strains or lines available

Original:	J:174679 Matsuoka RL, et al., Class 5 transmembrane semaphorins control selective Mammalian retinal lamination and function. Neuron. 2011 Aug 11;71(3):460-73
All:	4 reference(s)