Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sema5atm1.2Alk
Name:	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A; targeted mutation 1.2, Alex L Kolodkin
MGI ID:	MGI:5284881
Synonyms:	Sema5A-
Gene:	Sema5a  Location: Chr15:32244959-32696487 bp, + strand  Genetic Position: Chr15, 13.02 cM
Alliance:	Sema5atm1.2Alk page

Germline Transmission:	Earliest citation of germline transmission: J:174679
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted upstream of exon 6 and an FRT flanked inverted neo cassette and second loxP site were inserted downstream of exon 6 via homologous recombination. Recombinase mediated recombination removed the neo cassette and exon 6. Western blot analysis confirmed the absence of protein expression in homozygous mice. (J:174679)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sema5a Mutation:	65 strains or lines available

Original:	J:174679 Matsuoka RL, et al., Class 5 transmembrane semaphorins control selective Mammalian retinal lamination and function. Neuron. 2011 Aug 11;71(3):460-73
All:	3 reference(s)