Gene Expression Data
Assay Details
|
Assay
|
|
Reference:
|
J:58502
Bourdeau A, et al., A murine model of hereditary hemorrhagic telangiectasia [see comments]. J Clin Invest. 1999 Nov;104(10):1343-51
|
|
Assay type:
|
In situ reporter (knock in)
|
|
MGI Accession ID:
|
MGI:5141466
|
|
Gene symbol:
|
Eng
|
|
Gene name:
|
endoglin
|
|
Reporter:
|
lacZ
|
|
|
Direct Detection
|
|
|
Results
|
Specimen
2 E9.0 +/-:
embryonic day 9.0; Engtm1Mle/Eng +
(more  )
Specimen
2 E9.0 +/-:
(close  )
|
Genetic Background:
|
involves: 129P2/OlaHsd * C57BL/6
|
|
Mutant Allele(s):
|
Engtm1Mle/Eng+
|
|
Age:
|
embryonic day 9.0
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
Specimen
2 E9.0 -/-:
(close )
|
Genetic Background:
|
involves: 129P2/OlaHsd * C57BL/6
|
|
Mutant Allele(s):
|
Engtm1Mle/Engtm1Mle
|
|
Age:
|
embryonic day 9.0
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
Specimen
2 E9.5 +/-:
embryonic day 9.5; Engtm1Mle/Eng +
(more )
Specimen
2 E9.5 +/-:
(close )
|
Genetic Background:
|
involves: 129P2/OlaHsd * C57BL/6
|
|
Mutant Allele(s):
|
Engtm1Mle/Eng+
|
|
Age:
|
embryonic day 9.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
Specimen
2 E9.5 -/-:
(close )
|
Genetic Background:
|
involves: 129P2/OlaHsd * C57BL/6
|
|
Mutant Allele(s):
|
Engtm1Mle/Engtm1Mle
|
|
Age:
|
embryonic day 9.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
Specimen
2 E10.5 +/-:
embryonic day 10.5; Engtm1Mle/Eng +
(more )
Specimen
2 E10.5 +/-:
(close )
|
Genetic Background:
|
involves: 129P2/OlaHsd * C57BL/6
|
|
Mutant Allele(s):
|
Engtm1Mle/Eng+
|
|
Age:
|
embryonic day 10.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
Specimen
2 E10.5 -/-:
(close )
|
Genetic Background:
|
involves: 129P2/OlaHsd * C57BL/6
|
|
Mutant Allele(s):
|
Engtm1Mle/Engtm1Mle
|
|
Age:
|
embryonic day 10.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
Specimen
3a:
embryonic day 9.0; Engtm1Mle/Eng +
(more )
Specimen
3a:
(close )
|
Genetic Background:
|
involves: 129P2/OlaHsd * C57BL/6
|
|
Mutant Allele(s):
|
Engtm1Mle/Eng+
|
|
Age:
|
embryonic day 9.0
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
Specimen
3b:
(close )
|
Genetic Background:
|
involves: 129P2/OlaHsd * C57BL/6
|
|
Mutant Allele(s):
|
Engtm1Mle/Engtm1Mle
|
|
Age:
|
embryonic day 9.0
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS14: extraembryonic vascular system |
Present |
|
3b
|
Expression is present in the capillary plexus of the yolk sac, but the vessel branching seen in the heterozygotes is not seen.
|
Specimen
3c:
embryonic day 9.0; Engtm1Mle/Eng +
(more )
Specimen
3c:
(close )
|
Genetic Background:
|
involves: 129P2/OlaHsd * C57BL/6
|
|
Mutant Allele(s):
|
Engtm1Mle/Eng+
|
|
Age:
|
embryonic day 9.0
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Embedding:
|
Paraffin
|
Specimen
3d:
(close )
|
Genetic Background:
|
involves: 129P2/OlaHsd * C57BL/6
|
|
Mutant Allele(s):
|
Engtm1Mle/Engtm1Mle
|
|
Age:
|
embryonic day 9.0
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Embedding:
|
Paraffin
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS14: extraembryonic vascular system |
Present |
|
3d
|
Expression is present in the capillary plexus of the yolk sac, but the vessel branching seen in the heterozygotes is not seen.
|
Specimen
3e:
embryonic day 9.5; Engtm1Mle/Eng +
(more )
Specimen
3e:
(close )
|
Genetic Background:
|
involves: 129P2/OlaHsd * C57BL/6
|
|
Mutant Allele(s):
|
Engtm1Mle/Eng+
|
|
Age:
|
embryonic day 9.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
Specimen
3f:
(close )
|
Genetic Background:
|
involves: 129P2/OlaHsd * C57BL/6
|
|
Mutant Allele(s):
|
Engtm1Mle/Engtm1Mle
|
|
Age:
|
embryonic day 9.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS15: extraembryonic vascular system |
Present |
|
3f
|
Expression is present in the endothelial cells, but the capillary plexus is disorganized and there are no vitelline vessels.
|
Specimen
3g:
embryonic day 9.5; Engtm1Mle/Eng +
(more )
Specimen
3g:
(close )
|
Genetic Background:
|
involves: 129P2/OlaHsd * C57BL/6
|
|
Mutant Allele(s):
|
Engtm1Mle/Eng+
|
|
Age:
|
embryonic day 9.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Embedding:
|
Paraffin
|
Specimen
3h:
(close )
|
Genetic Background:
|
involves: 129P2/OlaHsd * C57BL/6
|
|
Mutant Allele(s):
|
Engtm1Mle/Engtm1Mle
|
|
Age:
|
embryonic day 9.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Embedding:
|
Paraffin
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS15: extraembryonic vascular system |
Present |
|
3h
|
Expression is present in the endothelial cells, but the capillary plexus is disorganized and there are no vitelline vessels.
|
Specimen
3m:
embryonic day 9.0; Engtm1Mle/Eng +
(more )
Specimen
3m:
(close )
|
Genetic Background:
|
involves: 129P2/OlaHsd * C57BL/6
|
|
Mutant Allele(s):
|
Engtm1Mle/Eng+
|
|
Age:
|
embryonic day 9.0
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Embedding:
|
Paraffin
|
Specimen
3n:
(close )
|
Genetic Background:
|
involves: 129P2/OlaHsd * C57BL/6
|
|
Mutant Allele(s):
|
Engtm1Mle/Engtm1Mle
|
|
Age:
|
embryonic day 9.0
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Embedding:
|
Paraffin
|
Specimen
4 E9.0 +/-:
embryonic day 9.0; Engtm1Mle/Eng +
(more )
Specimen
4 E9.0 +/-:
(close )
|
Genetic Background:
|
involves: 129P2/OlaHsd * C57BL/6
|
|
Mutant Allele(s):
|
Engtm1Mle/Eng+
|
|
Age:
|
embryonic day 9.0
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Embedding:
|
Paraffin
|
Specimen
4 E9.0 -/-:
(close )
|
Genetic Background:
|
involves: 129P2/OlaHsd * C57BL/6
|
|
Mutant Allele(s):
|
Engtm1Mle/Engtm1Mle
|
|
Age:
|
embryonic day 9.0
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Embedding:
|
Paraffin
|
Specimen
4 E9.5 +/-:
embryonic day 9.5; Engtm1Mle/Eng +
(more )
Specimen
4 E9.5 +/-:
(close )
|
Genetic Background:
|
involves: 129P2/OlaHsd * C57BL/6
|
|
Mutant Allele(s):
|
Engtm1Mle/Eng+
|
|
Age:
|
embryonic day 9.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Embedding:
|
Paraffin
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS15: heart |
Present |
|
4_E9.5 End+/-
|
Areas of expression include some mesenchymal cells.
|
Specimen
4 E9.5 -/-:
(close )
|
Genetic Background:
|
involves: 129P2/OlaHsd * C57BL/6
|
|
Mutant Allele(s):
|
Engtm1Mle/Engtm1Mle
|
|
Age:
|
embryonic day 9.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Embedding:
|
Paraffin
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS15: heart |
Present |
|
4_E9.5 End-/-
|
There is no expression in mesenchymal cells, indicating the endocardial-mesenchymal transformation did not occur.
|
Specimen
4 E10.5 +/-:
embryonic day 10.5; Engtm1Mle/Eng +
(more )
Specimen
4 E10.5 +/-:
(close )
|
Genetic Background:
|
involves: 129P2/OlaHsd * C57BL/6
|
|
Mutant Allele(s):
|
Engtm1Mle/Eng+
|
|
Age:
|
embryonic day 10.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Embedding:
|
Paraffin
|
Specimen
4 E10.5 -/-:
(close )
|
Genetic Background:
|
involves: 129P2/OlaHsd * C57BL/6
|
|
Mutant Allele(s):
|
Engtm1Mle/Engtm1Mle
|
|
Age:
|
embryonic day 10.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Embedding:
|
Paraffin
|
Specimen
6c:
postnatal; Engtm1Mle/Eng +
(more )
Specimen
6c:
(close )
|
Genetic Background:
|
129P2/OlaHsd-Engtm1Mle
|
|
Mutant Allele(s):
|
Engtm1Mle/Eng+
|
|
Age:
|
postnatal
|
|
Sex:
|
Not Specified
|
|
Type:
|
whole mount
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS28: blood vessel endothelium |
Present |
|
6c
|
In the ear, expression is present in a network of capillaries, as well as in a small telangiectasia.
|
Specimen
6e:
postnatal; Engtm1Mle/Eng +
(more )
Specimen
6e:
(close )
|
Genetic Background:
|
129P2/OlaHsd-Engtm1Mle
|
|
Mutant Allele(s):
|
Engtm1Mle/Eng+
|
|
Age:
|
postnatal
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Embedding:
|
Paraffin
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS28: blood vessel endothelium |
Present |
|
6e
|
Expression is present in several small capillaries, as well as in the endoothelium of a telangiectasia.
|
|
Analysis Tools