Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Nlrx1tm1Jpyt
Name:	NLR family member X1; targeted mutation 1, Jenny P Y Ting
MGI ID:	MGI:5141085
Gene:	Nlrx1  Location: Chr9:44164014-44179896 bp, - strand  Genetic Position: Chr9, 24.84 cM
Alliance:	Nlrx1tm1Jpyt page

Germline Transmission:	Earliest citation of germline transmission: J:173995
Parent Cell Line:	iTL IC1 (ES Cell)
Strain of Origin:	C57BL/6NTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 4 and 5 were replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on fibroblasts. (J:173995)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nlrx1 Mutation:	35 strains or lines available

Original:	J:173995 Allen IC, et al., NLRX1 Protein Attenuates Inflammatory Responses to Infection by Interfering with the RIG-I-MAVS and TRAF6-NF-kappaB Signaling Pathways. Immunity. 2011 Jun 24;34(6):854-65
All:	17 reference(s)