Cd1d1<tm1.2Aben> Targeted Allele Detail MGI Mouse (MGI:5085993)

Cd1d1^tm1.2Aben
Targeted Allele Detail

Summary

Symbol:	Cd1d1^tm1.2Aben
Name:	CD1d1 antigen; targeted mutation 1.2, Albert Bendelac
MGI ID:	MGI:5085993
Synonyms:	CD1.1 KO, Cd1d1/Cd1d2^tm1.2Aben
Gene:	Cd1d1 Location: Chr3:86903141-86906748 bp, - strand Genetic Position: Chr3, 37.91 cM
Alliance:	Cd1d1^tm1.2Aben page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:174415
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Cre-mediated recombination removed exons 2 through 6 of and the neo cassette. (J:174415)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Cd1d1 Mutation:	30 strains or lines available

Notes

Because the C57BL/6 ES cells used to generate the allele contain a natural frameshift mutation in Cd1d2 that prevents its surface expression, deletion of Cd1d1 is sufficient to abolish all CD1D protein from the cell surface.

References

Original:	J:174415 Bendelac A, Direct Data Submission 2011/08/15. MGI Direct Data Submission. 2011;
All:	12 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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