Tg(CMV-CASP3)17Edge
Transgene Detail
|
|
| Symbol: |
Tg(CMV-CASP3)17Edge |
| Name: |
transgene insertion 17, Albert Edge |
| MGI ID: |
MGI:5014208 |
| Synonyms: |
Mos-iCsp3 |
| Transgene: |
Tg(CMV-CASP3)17Edge Location: unknown
|
| Alliance: |
Tg(CMV-CASP3)17Edge page
|
|
|
|
| Transgene Type: |
|
Transgenic (Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter) |
| Mutation: |
|
Insertion
|
| |
|
Tg(CMV-CASP3)17Edge expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
CASP3 (836) |
|
|
|
| |
|
Mutation details: The Mos-iCsp3 transgene was designed with (from 5' to 3') a CMV promoter, a loxH site, a beta-galactosidase (lacZ) gene, a V5-tag (derived from the paramyxovirus of simian virus 5 (SV5)), a 6x-histidine-tag, a polyadenylation (polyA) signal, and a loxP . This floxed-lacZ-STOP cassette was followed by a myristoylation sequence, two tandem FK506-binding sites (Fvs), a human Caspase 3 (CASP3) gene, a haemagglutinin (HA) tag, and a second (polyA) signal. Lines 14 and 17 were generated.
(J:173515)
|
|
|
| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
|
|
| Original: |
J:173515 Fujioka M, et al., Generating mouse models of degenerative diseases using Cre/lox-mediated in vivo mosaic cell ablation. J Clin Invest. 2011 Jun 1;121(6):2462-9 |
| All: |
3 reference(s) |
|
Analysis Tools
