Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Rgs16tm1Tmw
Name:	regulator of G-protein signaling 16; targeted mutation 1, Thomas M Wilkie
MGI ID:	MGI:5004805
Gene:	Rgs16  Location: Chr1:153616099-153621212 bp, + strand  Genetic Position: Chr1, 65.43 cM
Alliance:	Rgs16tm1Tmw page

Germline Transmission:	Earliest citation of germline transmission: J:172091
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: A loxP site was inserted upstream of exon 5. An FRT-flanked neomycin resistance cassette with a loxP site was inserted downstream of exon 5. Cre-mediated recombination removed exon 5. The absence of protein expression was confirmed by western blot analysis. (J:172091)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rgs16 Mutation:	20 strains or lines available

Original:	J:172091 Pashkov V, et al., Regulator of G Protein Signaling (RGS16) Inhibits Hepatic Fatty Acid Oxidation in a Carbohydrate Response Element-binding Protein (ChREBP)-dependent Manner. J Biol Chem. 2011 Apr 29;286(17):15116-25
All:	1 reference(s)