Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Itga8tm1.1Rdav
Name:	integrin alpha 8; targeted mutation 1.1, Ronald Davis
MGI ID:	MGI:4948106
Synonyms:	f(a8), fA8, falpha8, f(alpha8), floxed alpha8-integrin
Gene:	Itga8  Location: Chr2:12111443-12306733 bp, - strand  Genetic Position: Chr2, 9.12 cM
Alliance:	Itga8tm1.1Rdav page

Germline Transmission:	Earliest citation of germline transmission: J:170959
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A targeting vector was designed to insert a loxP site just upstream of exon 29, and also insert a loxP-flanked TK-neo cassette about 4kb downstream of the STOP codon in exon 30 of the Itga8 gene (also called integrin alpha 8, alpha8-integrin, or a8-integrin). Cre-mediated recombination removed the TK-neo selection cassette, leaving a single loxP site upstream of exon 29 and a single loxP site downstream of exon 30. (J:170959)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Itga8 Mutation:	74 strains or lines available

Original:	J:170959 Chan CS, et al., alpha8-integrins are required for hippocampal long-term potentiation but not for hippocampal-dependent learning. Genes Brain Behav. 2010 Jun 1;9(4):402-10
All:	2 reference(s)