Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Juptm1.1Glr
Name:	junction plakoglobin; targeted mutation 1.1, Glenn L Radice
MGI ID:	MGI:4947239
Synonyms:	PGflox
Gene:	Jup  Location: Chr11:100259784-100288589 bp, - strand  Genetic Position: Chr11, 63.47 cM
Alliance:	Juptm1.1Glr page

Germline Transmission:	Earliest citation of germline transmission: J:170618
Parent Cell Line:	TL1/TL-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted upstream of exon 1, and a loxP site and an FRT-flanked neo cassette were introduced into intron 1 via homologous recombination. Flp mediated recombination removed the neo cassette leaving exon 1 floxed. (J:170618)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Jup Mutation:	162 strains or lines available

Original:	J:170618 Li J, et al., Cardiac tissue-restricted deletion of plakoglobin results in progressive cardiomyopathy and activation of {beta}-catenin signaling. Mol Cell Biol. 2011 Mar;31(6):1134-44
All:	10 reference(s)