Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ciao3tm1.1Fsl
Name:	cytosolic iron-sulfur assembly component 3; targeted mutation 1.1, Frank Lee
MGI ID:	MGI:4946831
Synonyms:	Iop1 f
Gene:	Ciao3  Location: Chr17:25992750-26002306 bp, + strand  Genetic Position: Chr17, 12.88 cM
Alliance:	Ciao3tm1.1Fsl page

Germline Transmission:	Earliest citation of germline transmission: J:170523
Parent Cell Line:	EAP6 (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A targeting vector was designed to insert a loxP site upstream of exon 1 followed by an frt-flanked neomycin resistance (neo) cassette, and a second loxP site downstream of exon 1 of the nuclear prelamin A recognition factor-like (Narfl or Iop1) gene. Flp-mediated recombination removed the neo cassette. (J:170523)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ciao3 Mutation:	28 strains or lines available

Original:	J:170523 Song D, et al., Mouse knock-out of IOP1 protein reveals its essential role in mammalian cytosolic iron-sulfur protein biogenesis. J Biol Chem. 2011 May 6;286(18):15797-805
All:	1 reference(s)