Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Nrxn3tm4.1Sud
Name:	neurexin III; targeted mutation 4.1, Thomas C Sudhof
MGI ID:	MGI:4946102
Synonyms:	Nrx3ss4+, NS4
Gene:	Nrxn3  Location: Chr12:88689646-90301709 bp, + strand  Genetic Position: Chr12, 42.94 cM
Alliance:	Nrxn3tm4.1Sud page

Germline Transmission:	Earliest citation of germline transmission: J:170231
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Modified isoform(s)) Mutations:    Insertion, Nucleotide substitutions   Mutation details: A targeting vector was designed to insert a loxP site upstream of exon 20 (alternative splice site 4) followed by a frt-flanked neomycin resistance (neo) cassette, and a second loxP site downstream of exon 20. The less common splice acceptor sequence of exon 20 (TGTTTTTTAAACTTTAAAG) was substituted with a much more common one (TGTTTTTTCGTCTTCCTAG) to make the exon always incorporated in the transcript. (J:170231)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nrxn3 Mutation:	80 strains or lines available

Original:	J:170231 Sudhof TC, Direct Data Submission 2011/04/11. MGI Direct Data Submission. 2011;
All:	3 reference(s)