Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ncstntm1Sud
Name:	nicastrin; targeted mutation 1, Thomas C Sudhof
MGI ID:	MGI:4943563
Gene:	Ncstn  Location: Chr1:171893580-171910356 bp, - strand  Genetic Position: Chr1, 79.54 cM
Alliance:	Ncstntm1Sud page

Germline Transmission:	Earliest citation of germline transmission: J:149506
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A neomycin resistance cassette, flanked by loxP and Frt sites was introduced to intron 2 and an additional loxP site was placed in intron 3. Floxed homozygous mice express intact nicastrin gene. (J:149506)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ncstn Mutation:	33 strains or lines available

Original:	J:149506 Tabuchi K, et al., Conditional forebrain inactivation of nicastrin causes progressive memory impairment and age-related neurodegeneration. J Neurosci. 2009 Jun 3;29(22):7290-301
All:	2 reference(s)