Summary | Mutation origin | Mutation description | Find Mice (IMSR) | Notes | References

Symbol:	Hgftm1.1(HGF)Aveo
Name:	hepatocyte growth factor; targeted mutation 1.1, AVEO Pharmaceuticals Inc
MGI ID:	MGI:4939654
Synonyms:	hHGFki
Gene:	Hgf  Location: Chr5:16758493-16825150 bp, + strand  Genetic Position: Chr5, 7.07 cM, cytoband A2-A3
Alliance:	Hgftm1.1(HGF)Aveo page

Germline Transmission:	Earliest citation of germline transmission: J:169053
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting vector was designed to replace exons 3-6 of the mouse hepatocyte growth factor (Hgf) locus with a cDNA sequence encoding exons 2-18 of the human hepatocyte growth factor (HGF), a polyA signal, and a frt-flanked PGK-neo cassette. Flp-mediated recombination removed the neo cassette. (J:169053)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Hgf Mutation:	55 strains or lines available

Original:	J:169053 Rideout WM 3rd, Direct Data Submission 2011/03/02. MGI Direct Data Submission. 2011;
All:	3 reference(s)