Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Csf2/Il3tm1.1(CSF2,IL3)Flv
Name:	interleukin 3; targeted mutation 1.1, Richard A Flavell
MGI ID:	MGI:4887881
Gene:	Il3  Location: Chr11:54156129-54158103 bp, - strand  Genetic Position: Chr11, 32.13 cM, cytoband B1
Alliance:	Csf2/Il3tm1.1(CSF2,IL3)Flv page

Germline Transmission:	Earliest citation of germline transmission: J:168302
Parent Cell Line:	V17 (ES Cell)
Strain of Origin:	BALB/cAnNTac x 129S4/SvJae

Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence) Mutations:    Insertion, Intergenic deletion   Mutation details: The coding region of Il3 through Csf2 was replaced with the corresponding human sequence. The human Il3 remains under the control of the mouse promoter while expression of Csf2 is controlled by the human promoter. Cre-mediated recombination removed the selection cassettes. (J:168302)

Strategy to generate the Csf2/Il3tm1.1(CSF2,IL3)Flv allele

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Il3 Mutation:	29 strains or lines available

Original:	J:168302 Willinger T, et al., Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung. Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2390-5
All:	15 reference(s)