Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Hormad1tm1Rajk Name: HORMA domain containing 1; targeted mutation 1, Aleksandar Rajkovic MGI ID: MGI:4887242 Gene: Hormad1  Location: Chr3:95466988-95494982 bp, + strand  Genetic Position: Chr3, 40.74 cM, cytoband F2 Alliance: Hormad1tm1Rajk page

Adult testes are atrophied in Hormad1tm1Rajk/Hormad1tm1Rajk mice Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:167522
Parent Cell Line:	AB2.1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 4 and 5 were replaced with a neomycin resistance gene. Small amounts of truncated RNA transcripts were detectable on RT-PCR, and Western blot analysis on testis extracts showed absence of the protein. (J:167522)

Generation of the Hormad1tm1Rajk allele

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	33 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hormad1 Mutation:	31 strains or lines available

Original:	J:167522 Shin YH, et al., Hormad1 mutation disrupts synaptonemal complex formation, recombination, and chromosome segregation in mammalian meiosis. PLoS Genet. 2010;6(11):e1001190
All:	6 reference(s)