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Gt(ROSA)26Sortm37(H1/tetO-RNAi:Tafazzin)Arte
Targeted Allele Detail
Summary
Symbol: Gt(ROSA)26Sortm37(H1/tetO-RNAi:Tafazzin)Arte
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 37, TaconicArtemis
MGI ID: MGI:4887237
Synonyms: Gt(ROSA)26Sortm1(H1/tetO-RNAi:Taz,CAG-tetR)Bsf, Gt(ROSA)26Sortm37(H1/tetO-RNAi:Taz)Arte, ROSA26H1/tetO-shRNA:taz, TAZKD
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance: Gt(ROSA)26Sortm37(H1/tetO-RNAi:Tafazzin)Arte page
Defects of cardiac mitochondria and mitochondrion-associated membranes in Gt(ROSA)26Sortm37(H1/tetO-RNAi:Tafazzin)Arte/Gt(ROSA)26Sor+ mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:167527
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Inducible, Knockdown)
Inducer:    doxycycline/tetracycline
Mutation:    Insertion
  Gt(ROSA)26Sortm37(H1/tetO-RNAi:Tafazzin)Arte involves 1 genes/genome features (Tafazzin) View all
 
Mutation detailsA short hairpin RNA directed against Taz was targeted into the Rosa26 locus. The shRNA sequence is under the regulation of the H1/tetO operator fusion promoter. Correct mRNA knock-down was confirmed in embryonic stem cells. (J:167527)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  935 strains or lines available
References
Original:  J:167527 Acehan D, et al., Cardiac and skeletal muscle defects in a mouse model of human barth syndrome. J Biol Chem. 2011 Jan 14;286(2):899-908
All:  40 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory