Summary | Transgene origin | Transgene description | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Tg(DYRK1A)36Wjs
Name:	transgene insertion 36, Woo-Joo Song
MGI ID:	MGI:4867514
Synonyms:	DYRK1A BAC TG
Transgene:	Tg(DYRK1A)36Wjs  Location: unknown
Alliance:	Tg(DYRK1A)36Wjs page

Strain of Origin:

C57BL/6NCrjBgi

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Tg(DYRK1A)36Wjs expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human DYRK1A (1859) Dyrk1a  (MGI:1330299)   Mutation details: This transgene consists of a bacterial artificial chromosome clone containing the complete human DYRK1A genomic DNA fragment, including the endogenous promoter (777J19 BAC clone from the RPCI-11 human BAC library). FISH and quantitative PCR analysis shows a single chromosomal integration of the DNA and about a 1.5-fold overexpression of total Dyrk1a (both mouse and human) protein. Two lines 36 and 46 were created, with line 36 entered as the representative line. (J:111293)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:111293 Ahn KJ, et al., DYRK1A BAC transgenic mice show altered synaptic plasticity with learning and memory defects. Neurobiol Dis. 2006 Jun;22(3):463-72
All:	8 reference(s)