Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Dph2tm2(EUCOMM)Wtsi
Name:	DPH2 homolog; targeted mutation 2, Wellcome Trust Sanger Institute
MGI ID:	MGI:4840638
Gene:	Dph2  Location: Chr4:117745838-117749220 bp, - strand  Genetic Position: Chr4, 53.74 cM
Alliance:	Dph2tm2(EUCOMM)Wtsi page
IMPC:	Dph2 gene page

Mutant Cell Lines:	EPD0438_5_C04, EPD0438_5_G07
Germline Transmission:	Earliest citation of germline transmission: J:175295
Parent Cell Line:	JM8A3.N1 (ES Cell)
Strain of Origin:	C57BL/6N-Atm1Brd
Project Collection:	EUCOMM

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion     Vector: L1L2_Bact_P   Mutation details: The insertion of the L1L2_Bact_P cassette created a deletion of size 1973 starting at position 117746669 and ending at position 117748642 of Chromosome 4 (Genome Build GRCm39). This deletion results in the removal of functionally critical exon(s). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. (J:155845, J:173534)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available      Cell Lines: 1 line available
Carrying any Dph2 Mutation:	19 strains or lines available

Original:	J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010;
All:	4 reference(s)