Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(Igh-2-12Vh/Ighma)1Shc
Name:	transgene insertion 1, Stephen Clarke
MGI ID:	MGI:4840370
Synonyms:	2-12H Tg, IgSm, Tg(Igh-V2-12H/Igh-6)1Shc
Transgene:	Tg(Igh-2-12Vh/Ighma)1Shc  Location: unknown
Alliance:	Tg(Igh-2-12Vh/Ighma)1Shc page

Strain of Origin:

(C57BL/6 x SJL)F1

Transgene Type:    Transgenic (Inserted expressed sequence) Mutation:    Insertion   Tg(Igh-2-12Vh/Ighma)1Shc expresses 2 genes Transgene expresses: Organism Expressed Gene Note mouse Igh (MGI:96442) mouse Ighm (MGI:96448)   Mutation details: This transgene contains the unmutated, functionally rearranged immunoglobulin heavy-chain variable region segments, comprising V558(DSP2)J4, from the MRL/MP-Faslpr-derived hybridoma 2-12 joined to the mu constant region (Ighm) exons from BALB/c, which is of the Igha allotype. The encoded IGH chain, in combination with various immunoglobulin light chains, recognizes the nuclear antigen Sm and single stranded, but not double stranded, DNA. (J:3925, J:133722, J:160961)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available

Original:	J:133722 Santulli-Marotto S, et al., Autoreactive B cell regulation: peripheral induction of developmental arrest by lupus-associated autoantigens. Immunity. 1998 Feb;8(2):209-19
All:	11 reference(s)