Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ago2tm1.1Tara
Name:	argonaute RISC catalytic subunit 2; targeted mutation 1.1, Alexander Tarakhovsky
MGI ID:	MGI:4839762
Synonyms:	Ago2fl
Gene:	Ago2  Location: Chr15:72967693-73056777 bp, - strand  Genetic Position: Chr15, 33.92 cM
Alliance:	Ago2tm1.1Tara page

Germline Transmission:	Earliest citation of germline transmission: J:165967
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: An FRT-flanked neo cassette with a loxP site was inserted downstream of exon 11 and an additional loxP site was inserted btween exon 8 and 9. Flp-mediated recombination removed the neo cassette leaving exons 9 through 11 floxed. (J:165967)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ago2 Mutation:	54 strains or lines available

Original:	J:165967 O'Carroll D, et al., A Slicer-independent role for Argonaute 2 in hematopoiesis and the microRNA pathway. Genes Dev. 2007 Aug 15;21(16):1999-2004
All:	18 reference(s)