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Tardbptm1.1Pcw
Targeted Allele Detail
Summary
Symbol: Tardbptm1.1Pcw
Name: TAR DNA binding protein; targeted mutation 1.1, Philip C Wong
MGI ID: MGI:4834273
Synonyms: TardbpF, Tardbpflox
Gene: Tardbp  Location: Chr4:148696839-148711476 bp, - strand  Genetic Position: Chr4, 78.77 cM
Alliance: Tardbptm1.1Pcw page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:164406
Parent Cell Line:  V26.2 (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsExon 3 of the Tardbp gene was flanked by loxP sites. A neo cassette was inserted into exon 2. Mice carrying the mutant allele were crossed to Flp transgenic mice to delete the neo cassette. (J:164406)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 9 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tardbp Mutation:  59 strains or lines available
References
Original:  J:164406 Chiang PM, et al., Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism. Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16320-4
All:  20 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory