Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Atxn1ltm1.1Hzo
Name:	ataxin 1-like; targeted mutation 1.1, Huda Y Zoghbi
MGI ID:	MGI:4819750
Synonyms:	Atxn1ldp
Gene:	Atxn1l  Location: Chr8:110453083-110464371 bp, - strand  Genetic Position: Chr8, 57.22 cM
Alliance:	Atxn1ltm1.1Hzo page

Germline Transmission:	Earliest citation of germline transmission: J:119643
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Conditional ready) Mutations:    Duplication, Insertion   Atxn1ltm1.1Hzo involves 1 genes/genome features (Atxn1l) View all   Mutation details: Homologous recombination duplicated the gene. Cre mediated recombination removed the floxed neo cassette leaving a portion of the gene floxed. Western blot analysis confirmed increased protein expression. (J:119643)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Atxn1l Mutation:	24 strains or lines available

Original:	J:119643 Bowman AB, et al., Duplication of Atxn1l suppresses SCA1 neuropathology by decreasing incorporation of polyglutamine-expanded ataxin-1 into native complexes. Nat Genet. 2007 Mar;39(3):373-379
All:	3 reference(s)