Summary | Mutation origin | Mutation description | Tumor data | Find Mice (IMSR) | Notes | References

Symbol:	Gt(ROSA)26Sortm6(Gli1)Amc
Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 6, Andrew P McMahon
MGI ID:	MGI:4460761
Synonyms:	R26-Gli1, RosaGli1-FLAG
Gene:	Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance:	Gt(ROSA)26Sortm6(Gli1)Amc page

Germline Transmission:	Earliest citation of germline transmission: J:121411
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	129 and C57BL/6 and CBA and Swiss Webster

Allele Type:    Targeted (Conditional ready, Inserted expressed sequence, Reporter) Mutation:    Insertion   Gt(ROSA)26Sortm6(Gli1)Amc expresses 1 gene Knock-in expresses: Organism Expressed Gene Note mouse Gli1 (MGI:95727)   Mutation details: A full-length Gli1 cDNA followed by sequence for a C-terminal 3X FLAG tag, an IRES, the Venus fluorescent reporter gene, an intron and poly(A) signal sequences were inserted into the locus downstream of a splice acceptor and loxP site flanked neomycin resistance gene cassette. Upon cre expression, the neo cassette is removed and FLAG tagged Gli1 gene and Venus gene expressed. (J:121411)

List all tumor models in MMHCdb carrying Gt(ROSA)26Sortm6(Gli1)Amc

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:	942 strains or lines available

Original:	J:121411 Vokes SA, et al., Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning. Development. 2007 May;134(10):1977-89
All:	8 reference(s)