Batftm1.1Ejt
Targeted Allele Detail
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| Symbol: |
Batftm1.1Ejt |
| Name: |
basic leucine zipper transcription factor, ATF-like; targeted mutation 1.1, Elizabeth J Taparowsky |
| MGI ID: |
MGI:4459733 |
| Synonyms: |
Batfdelta Z |
| Gene: |
Batf Location: Chr12:85733494-85755861 bp, + strand Genetic Position: Chr12, 39.78 cM
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| Alliance: |
Batftm1.1Ejt page
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Low IgG1 and IgG2c levels in spleen and absence of germinal centers in sRBC-immunized Batftm1.1Ejt/Batftm1.1Ejt mice
Show the 1 phenotype image(s) involving this allele.
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| Germline Transmission: |
Earliest citation of germline transmission:
J:160935
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
129S/Sv
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A loxP site was inserted into intron 2 and a loxP site flanked neomycin resistance gene cassette into intron 3. HA epitope sequence was added to the the 3' end of the coding region in exon 3. Exon 3 and the neo cassette were removed by cre-mediated recombination. Immunoblots of splenocytes failed to detect any protein.
(J:160935)
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Generation of the Batftm1.1Ejt allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Batf Mutation: |
14 strains or lines available
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| Original: |
J:160935 Betz BC, et al., Batf coordinates multiple aspects of B and T cell function required for normal antibody responses. J Exp Med. 2010 May 10;207(5):933-42 |
| All: |
6 reference(s) |
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Analysis Tools
