Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Slc6a4tm2(SLC6A4)Kres
Name:	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4; targeted mutation 1, Kerry Ressler
MGI ID:	MGI:4457113
Synonyms:	hSERT mut knockin
Gene:	Slc6a4  Location: Chr11:76889429-76923166 bp, + strand  Genetic Position: Chr11, 46.18 cM
Alliance:	Slc6a4tm2(SLC6A4)Kres page

Germline Transmission:	Earliest citation of germline transmission: J:331750
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence) Mutations:    Insertion, Intragenic deletion   Mutation details: Full-length mutant (II/552,553/VT - MS/558,559/SN - SI/574,575/TT) human SLC6A4 cDNA carrying replaces exons 2-6 of the targeted mouse gene. (J:331750)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slc6a4 Mutation:	51 strains or lines available

Original:	J:331750 Murray KE, et al., In vivo investigation of escitalopram's allosteric site on the serotonin transporter. Pharmacol Biochem Behav. 2016 Feb;141:50-7
All:	2 reference(s)