Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Lrp5tm1.1Mawa
Name:	low density lipoprotein receptor-related protein 5; targeted mutation 1.1, Matthew Warman
MGI ID:	MGI:4453212
Synonyms:	G, Lrp5 G171V
Gene:	Lrp5  Location: Chr19:3634828-3736564 bp, - strand  Genetic Position: Chr19, 3.33 cM, cytoband B
Alliance:	Lrp5tm1.1Mawa page

Germline Transmission:	Earliest citation of germline transmission: J:172746
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Humanized sequence) Mutations:    Insertion, Nucleotide substitutions   Mutation details: Glycine 170 of the targeted gene was converted to valine (equivalent to the human G171V missense mutation) via site-directed mutagenesis. Cre mediated recombination removed the floxed neo cassette. (J:172746)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lrp5 Mutation:	81 strains or lines available

Original:	J:172746 Cui Y, et al., Lrp5 functions in bone to regulate bone mass. Nat Med. 2011 Jun;17(6):684-91
All:	9 reference(s)