Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Fzd1tm1.1Nat
Name:	frizzled class receptor 1; targeted mutation 1.1, Jeremy Nathans
MGI ID:	MGI:4442608
Gene:	Fzd1  Location: Chr5:4803839-4808035 bp, - strand  Genetic Position: Chr5, 2.61 cM
Alliance:	Fzd1tm1.1Nat page

Germline Transmission:	Earliest citation of germline transmission: J:159437
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: The coding region for a nuclear-localized beta-galactosidase (nLacZ; using an SV40 nuclear localization signal) was targeted to the Fzd1 locus by homologous recombination. The nLacZ sequences replace the Fzd1 open reading frame. A LoxP-flanked neo selectable marker used for ES cell selection was removed by subsequent crossing to a mouse line expressing germline Cre recombinase. Sequences from the E coli tetracycline resistance gene (TetR) are included immediately 3' of the nLacZ sequences and are part of the 3' untranslated region of the nLacZ transcript. (J:159437)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fzd1 Mutation:	29 strains or lines available

Original:	J:159437 Nathans J, DDS for Fzd1tm1.1Nat. MGI Direct Data Submission. 2010;
All:	4 reference(s)