Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tie1tm1.1Scba
Name:	tyrosine kinase with immunoglobulin-like and EGF-like domains 1; targeted mutation 1.1, Scott Baldwin
MGI ID:	MGI:4441288
Gene:	Tie1  Location: Chr4:118328388-118347046 bp, - strand  Genetic Position: Chr4, 54.67 cM
Alliance:	Tie1tm1.1Scba page

Germline Transmission:	Earliest citation of germline transmission: J:158668
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion     Cre mediated recombination removed the neo cassette and exon 1. (J:158668)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tie1 Mutation:	67 strains or lines available

Original:	J:158668 Qu X, et al., Abnormal embryonic lymphatic vessel development in Tie1 hypomorphic mice. Development. 2010 Apr;137(8):1285-95
All:	3 reference(s)