Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Dkkl1tm1.1Mldp
Name:	dickkopf-like 1; targeted mutation 1.1, Melvin DePamphilis
MGI ID:	MGI:4438465
Gene:	Dkkl1  Location: Chr7:44856943-44861571 bp, - strand  Genetic Position: Chr7, 29.19 cM
Alliance:	Dkkl1tm1.1Mldp page

Germline Transmission:	Earliest citation of germline transmission: J:158272
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting vector was designed to insert loxP sites flanking exons 2-4 of the Dickkopf-Like 1 (Dkkl1) gene, and a frt-flanked neomycin resistance (neo) cassette upstream of the 3' loxP site. Cre mediated recombination removed exons 2 through 4 and the frt-flanked neo cassette. The absence of protein expression was confirmed by immunohistochemistry on testis samples. (J:158272)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dkkl1 Mutation:	13 strains or lines available

Original:	J:158272 Kaneko KJ, et al., The acrosomal protein Dickkopf-like 1 (DKKL1) is not essential for fertility. Fertil Steril. 2010 Mar 15;93(5):1526-32
All:	2 reference(s)