Summary | Transgene origin | Transgene description | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Tg(HTT*)1Xwy
Name:	transgene insertion 1, X William Yang
MGI ID:	MGI:4438230
Synonyms:	SA
Transgene:	Tg(HTT*)1Xwy  Location: unknown
Alliance:	Tg(HTT*)1Xwy page

Strain of Origin:

FVB

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Tg(HTT*)1Xwy expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human HTT (3064) Htt  (MGI:96067)   Mutation details: The 240 kb human bacterial artificial chromosome BAC(RP11-866L6), containing the entire 170 kb human Huntingtin (htt) genomic locus and approximately 20 kbp of 5' and 50 kbp of 3' flanking sequences, was modified by replacing the human htt exon 1 with a loxP-flanked human mutant htt exon 1 sequence (containing 97 mixed CAA-CAG repeats encoding a continuous polyglutamine (polyQ) stretch). Nucleotide substitution resulted in amino acid substitution of alanine for serine at positions 13 and 16. One line was created (no line number provided). (J:157723)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:157723 Gu X, et al., Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice. Neuron. 2009 Dec 24;64(6):828-40
All:	1 reference(s)