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Gene Expression Data
Assay Details
Assay
Reference: J:155794 Phoenix TN, et al., Spred1, a negative regulator of Ras-MAPK-ERK, is enriched in CNS germinal zones, dampens NSC proliferation, and maintains ventricular zone structure. Genes Dev. 2010 Jan 1;24(1):45-56
Assay type: RNA in situ
MGI Accession ID: MGI:4437633
Gene symbol: Spred1
Gene name: sprouty protein with EVH-1 domain 1, related sequence
Probe: Spred1 cDNA1
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 1A E11.5: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: telencephalon ventricular layer Strong Graded 1A E11.5 The strongest expression is near the apical edge where the principle progenitor cells reside, becoming more scattered toward the basal aspect of the venrtricular zone.
TS19: telencephalon Strong Regionally restricted 1A E11.5 Expression is in the midline anterior commissural plate.
Specimen 1A E14: embryonic day 14.0 (more )
Structure Level Pattern Image Note
TS22: cerebral cortex ventricular layer Present 1A E14
TS22: cerebral cortex subventricular zone Present 1A E14
Specimen 1A E17: embryonic day 17.0 (more )
Structure Level Pattern Image Note
TS25: cerebral cortex ventricular zone Strong 1A E17
TS25: cerebral cortex subventricular zone Present 1A E17
TS25: cortical plate Weak 1A E17 Expression is in differentiated neurons.
TS25: hippocampus Weak 1A E17 Expression is in differentiated neurons.
Specimen S1a: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: telencephalon ventricular layer Strong Graded S1a E11.5 The strongest expression is near the apical edge where the principle progenitor cells reside, becoming more scattered toward the basal aspect of the venrtricular zone.
TS19: telencephalon Strong Regionally restricted S1a E11.5 Expression is in the midline anterior commissural plate.
Specimen S1a: embryonic day 14.0 (more )
Structure Level Pattern Image Note
TS22: cerebral cortex subventricular zone Present S1a E14
TS22: cerebral cortex ventricular layer Present S1a E14
Specimen S1a: embryonic day 17.0 (more )
Structure Level Pattern Image Note
TS25: cerebral cortex ventricular zone Strong S1a E17
TS25: cerebral cortex subventricular zone Present S1a E17
TS25: cortical plate Weak S1a E17 Expression is in differentiated neurons.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory