Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Ush1ctm1Xzl
Name:	USH1 protein network component harmonin; targeted mutation 1, Xue Liu
MGI ID:	MGI:4437562
Gene:	Ush1c  Location: Chr7:45844774-45887927 bp, - strand  Genetic Position: Chr7, 29.66 cM, cytoband B3
Alliance:	Ush1ctm1Xzl page

Germline Transmission:	Earliest citation of germline transmission: J:158047
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The first four exons were replaced with a Beta galactosidase reporter and neomycin resistance genes, successfully eliminating expression of all of the many transcripts produced by this gene, including a, b, and c isoforms. (J:158047)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ush1c Mutation:	50 strains or lines available

Original:	J:158047 Tian C, et al., Ush1c gene expression levels in the ear and eye suggest different roles for Ush1c in neurosensory organs in a new Ush1c knockout mouse. Brain Res. 2010 Apr 30;1328:57-70
All:	6 reference(s)