Summary | Transgene origin | Transgene description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(Myh6*/tetO-Capn1)L2Gwd
Name:	transgene insertion L2, Gerald W Dorn II
MGI ID:	MGI:4437466
Synonyms:	Calpain 1 TG
Transgene:	Tg(Myh6*/tetO-Capn1)L2Gwd  Location: unknown
Alliance:	Tg(Myh6*/tetO-Capn1)L2Gwd page

Strain of Origin:

FVB/N

Transgene Type:    Transgenic (Inducible, Inserted expressed sequence) Inducer:    doxycycline/tetracycline Mutation:    Insertion   Tg(Myh6*/tetO-Capn1)L2Gwd expresses 1 gene Transgene expresses: Organism Expressed Gene Note mouse Capn1 (MGI:88263)   Mutation details: These MHCminTetO-Capn1 transgenic mice were generated by inserting the entire coding region of the mouse Calpain 1 gene into an MHCminTetO-promoter construct. The expression of this construct was driven by a mouse alpha-myosin heavy chain (alpha-MHC; Myh6) promoter under control of a tetracycline operator (tetO), followed by a human growth hormone polyadenylation (polyA) signal. This construct also contained 3 altered GATA sites and 2 altered thyroid-like response elements (TRE) maintaining low levels of cardiac-specific expression and decreased background. Three lines were created (L1, L2, and L3) with ascending levels of expression. (J:125131, J:133797)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:133797 Galvez AS, et al., Cardiomyocyte degeneration with calpain deficiency reveals a critical role in protein homeostasis. Circ Res. 2007 Apr 13;100(7):1071-8
All:	5 reference(s)