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Mirc30tm1.1Rdf
Targeted Allele Detail
Summary
Symbol: Mirc30tm1.1Rdf
Name: microRNA cluster 30, including Mir16-1 through Mir15a; targeted mutation 1.1, Riccardo Dalla-Favera
MGI ID: MGI:4437043
Gene: Mirc30  Location: Chr14:61869329-61869559 bp  Genetic Position: Chr14, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:156946
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsThe locus was floxed and an FRT flanked neo cassette was inserted centromeric to the locus by homologous recombination. The selection cassette was removed by flp mediated recombination. RT-PCR confirmed normal expression of the micro RNAs and Dleu2. (J:156946)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Mirc30tm1.1Rdf
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mirc30 Mutation:  4 strains or lines available
References
Original:  J:156946 Klein U, et al., The DLEU2/miR-15a/16-1 Cluster Controls B Cell Proliferation and Its Deletion Leads to Chronic Lymphocytic Leukemia. Cancer Cell. 2010 Jan 19;17(1):28-40
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory