Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Atp6v0a4tm1e(EUCOMM)Hmgu
Name:	ATPase, H+ transporting, lysosomal V0 subunit A4; targeted mutation 1e, Helmholtz Zentrum Muenchen GmbH
MGI ID:	MGI:4435817
Gene:	Atp6v0a4  Location: Chr6:38025418-38101521 bp, - strand  Genetic Position: Chr6, 17.5 cM, cytoband B1
IMPC:	Atp6v0a4 gene page

Mutant Cell Lines:	HEPD0522_3_B04, HEPD0522_3_H01
Germline Transmission:	Unknown
Parent Cell Line:	JM8.N4 (ES Cell)
Strain of Origin:	C57BL/6N
Project Collection:	EUCOMM

Allele Type:    Targeted (Null/knockout, Reporter) Mutation:    Insertion     Vector: L1L2_Bact_P   Mutation details: The L1L2_Bact_P cassette was inserted at position 38063452 of Chromosome 6 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. Insertion of this cassette creates a reporter knockout mouse. Cre expression will remove the neomycin selection cassette. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:157065)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 1 line available
Carrying any Atp6v0a4 Mutation:	31 strains or lines available

Original:	J:157065 Helmholtz Zentrum Muenchen GmbH, Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu). MGI Direct Data Submission. 2010-2015;
All:	1 reference(s)